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  • 姓  名:张勇民
  • 职称职务:教授、博士生导师
  • 联系电话:+33-1-44323335
  • 电子邮箱:yongmin.zhang@ens.fr
  • 办公地址:
个人简介

   19821月毕业于北京医学院药学系(现北京大学药学院),获理学学士学位。1983年在巴黎第11大学(巴黎南大学)药学院获硕士学位。1986年在巴黎第11大学药学院获法国国家博士学位,并获博士论文一等奖。1986年至1988年在北京医科大学(现北京大学医学部)药物化学博士后科研流动站工作,期间获得国家自然科学基金委员会青年科学基金和卫生部青年科学基金资助。19889月获中国卫生部19871988年度孙氏鼓励医学科研基金一等奖。198812月受聘于法国巴黎第11大学,任客座副教授,在药学院从事教学与科研工作。19891月获法国药学科学院论文奖,19897月在法国格勒诺布尔市召开的第25届国际药物化学大会上获药物化学研究鼓励奖。199010月任巴黎第11大学邀请教授。19912月受聘于法国国家科学研究中心,任化学部巴黎地区研究员,在法国国家科学研究中心与巴黎高等师范学校联合生命化学实验室从事糖化学研究。19928月转为终身研究员。1995年至1997年在美国华盛顿大学进行糖化学及糖生物学的合作研究。1999年通过法国教育部教授资格认证。自2000年起,先后在生物技术及生物医学领域主持2项中法先进研究计划项目。2001年获中国国家自然科学基金委员会海外青年学者合作研究基金(杰出青年基金B类),与北京大学开展合作研究。2002年受聘担任西北大学客座教授。2003年晋升为法国国家科学研究中心主任研究员。2004年受聘担任北京医药集团有限责任公司专家委员会委员,并担任浙江大学-巴黎高等师范学校药物化学联合实验室主任。2005年受聘担任浙江大学光彪特聘教授,北京大学天然药物及仿生药物国家重点实验室学术委员会委员。2006年担任兰州大学“教育部‘春晖计划’基地”学术委员会委员现任全法中国科技工作者协会理事长。主要从事糖化学研究,方向为:生物活性寡糖及寡糖脂的合成,碳糖的合成,环糊精的结构修饰。

近期发表学术论文:

 -    "Trimethylaluminium promoted rearrangements of unsaturated sugars into cyclohexanes". Cai Jia, Alan J. Pearce, Yves Blériot, Yongmin Zhang, Li-He Zhang, Matthieu Sollogoub, Pierre Sinaÿ, Tetrahedron : Asymmetry 2004, 15, 699-703.

 -     "Diisobutylaluminum hydride as molecular scalpel: the regioselective stripping of four methyl groups from permethylated -cyclodextrin". X. Luo, Y. Chen, J. G. Huber, Yongmin Zhang, P. Sinaÿ, C. R. Chimie 2004, 7(1), 25-28.

 -     "Studies on alkylphenols and alkylphenolic acids in the Sarcotesta of Ginkgo Biloba L.". H. Li, Z. He, Yongmin Zhang, P. Sinaÿ, Chinese Traditional and Herbal Drugs 2004, 35 (1), 18-20.

 -     "The first synthesis of substituted azepanes mimicking monosaccharides: a new class of potent glycosidase inhibitors". Hongqing Li, Yves Blériot, Caroline Chantereau, Jean-Maurice Mallet, Matthieu Sollocoub, Yongmin Zhang, Eliazar Rodriguez-Garcia, Pierre Vogel, Jesus Jiménez-Barbero, Pierre Sinaÿ, Org. Biomol. Chem. 2004, 2, 1492-1499.

 -      "Study of induced resistance of Tabacco to Phytophthora parasitica var. nicotianae by chemically synthesized oligosaccharides". Zhenyuan Zhu, Yongmin Zhang, Tong Xu, Acta Phytopathologica Sinica 2004, 34 (3), 231-236.

-      “Metabolites from mangrove endophytic fungus Dothiorella sp.”. Qingyan Xu, Jianfeng Wang, Yaojian Huang, Zhonghui Zheng, Siyang Song, Yongmin Zhang, Wenjin Su, Acta Oceanologica Sinica 2004, 23 (3), 541-547.

-     “Diisobutylaluminium hydride (DIBAL-H) as a molecular scalpel: a new mechanistic proposal for a spiroketal rearrangement”. Xiangbao Meng, Yongmin Zhang, Matthieu Sollogoub, Pierre Sinaÿ, Tetrahedron Lett. 2004, 45, 8165-8148.

 -     “Exploration on the cultivating method of Epimedium”. Chao Sun, Yongmin Zhang, Changhu Lin, Jianling Zou, Yan Zhong. China Journal of Traditional Chinese Medicine and Pharmacy (Zhongguo Yiyao Xuebao) 2004, 19 (suppl.), 223-225.

 -      “Specific and non specific interactions involving Lex determinant quantified by lipid vesicle micromanipulation”. Christine Gourier, Frédéric Pincet, Eric Perez, Yongmin Zhang, Jean-Maurice Mallet, Pierre Sinay, Glycoconjugate J. 2004, 21, 165-174.

 -     "Evaluation on medicinal plant resources and available use in Guizhou province". Chao Sun, Yongmin Zhang, Chinese Traditional and Herbal Drugs 2004, 35 (11), 1311-1315.

 -      Can small complex chains be treated as polymers”? C. Gourier, F. Pincet, T. Le Bouar, Yongmin Zhang, J. Esnault, J.-M. Mallet, P. Sinaÿ, E. Perez, Macromolecules 2004, 37, 8778-8784.

 -      “Polyhydroxyazepanes mimicking monosaccharides: synthesis of an -D-galacto-like  iminoheptitol”. Hongqing Li, Yves Blériot, Jean-Maurice Mallet, Yongmin Zhang, Eliazar Rodriguez-Garcia, Pierre Vogel, Silvia Mari, Jesus Jiménez-Barbero, Pierre Sinaÿ, Heterocycles, 2004, 64, 65-74.

 -      Study on new method to isolate ginkgolides A, B, C and bilobalide from EGB”. Jun He, Zhaofan He, Yongmin Zhang, Pierre Sinaÿ, Chinese Traditional and Herbal Drugs 2004, 35 (12), 1359-1360.

 -      “Synthesis of novel highly water-soluble 2:1 cyclodextrin/fullerene conjugates involving the secondary rim of -cyclodextrin”. Juan Yang, Yali Wang, André Rassat, Yongmin Zhang, Pierre Sinaÿ, Tetrahedron 2004, 60, 12163-12168.

 -      “New 1-amino-1-deoxy- and 2-amino-2-deoxy-polyhydroxyazepanes: synthesis and inhibition of glycosidases”. Hongqing Li, Yves Blériot, Jean-Maurice Mallet, Eliazar Rodriguez-Garcia, Pierre Vogel, Yongmin Zhang, Pierre Sinaÿ, Tetrahedron: Asymmetry, 2005, 16, 313-319.

 -      “Regioselective one-step synthesis of hexahydroxy permethylated b-cyclodextrin and unambiguous NMR analysis”. Yong Chen, J. Gaspard Huber, Yongmin Zhang, Pierre Sinaÿ. C. R. Chimie 2005, 8 (1), 27-30.

 -      “Synthesis of several new disaccharides”. Zhenyuan Zhu, Yongmin Zhang, Tong Xu, J. Zhejiang University (Engineering Science) 2005, 39 (2), 311-316.

 -      “The natural Lewis X bearing lipids promote membrane adhesion. Influence of ceramide on carbohydrate-carbohydrate bond formation”. Christine Gourier, Frédéric Pincet, Eric Perez, Yongmin Zhang, Zhenyuan Zhu, Jean-Maurice Mallet, Pierre Sinaÿ, Angew. Chem. Int. Ed. 2005, 44 (11), 1683-1687.

 -      “Concise biomimetic syntheses of bacteriohopanetetrol and its glucosamine derivative”. Weidong Pan, Yongmin Zhang, Guangyi Liang, Stéphane P. Vincent, Pierre Sinaÿ. Chem. Commun. 2005, 3445-3447.

 -      “First synthesis of 3’-deoxy Lewisx pentasaccharide”. Chafika Gourmala, Zhenyan Zhu, Yun Luo, Bo Tao Fan, Saïd Ghalem, Yongzhou Hu, Yongmin Zhang. Tetrahedron: Asymmetry 2005, 16, 3024-3029.

 -      “Study on the Glycoside Content of the Artificially Cultivated Epimedium Wushanense”. Chao Sun, Yongmin Zhang, Jianling Zou, Changhu Lin, Yan Zhong. China Journal of Traditional Chinese Medicine and Pharmacy (Zhonghua Zhongyiyao Zazhi) 2005, 20 (11), 670-671.

 -     “Synthesis of water-soluble 2-alkylcyclodextrin-C60 conjugates and their inclusion complexation in aqueous solution”. Yong Chen, Yali Wang, Pierre Sinaÿ, André Rassat, Yu Zhao, Yongmin Zhang. Tetrahedron 2006, 62, 2045-2049.

 -      “Nucleophilic opening of epoxyazepanes: expanding the family of polyhydroxyazepane-based glycosidase inhibitors”. Hongqing Li, Catherine Schütz, Sylvain Favre, Yongmin Zhang, Pierre Vogel, Pierre Sinaÿ, Yves Blériot. Org. Biomol. Chem. 2006, 4, 1653-1662.

 -     “Photophysical studies of six amphiphilic 2:1 cyclodextrin:[60]fullerene derivatives”. Annamaria Quaranta, Yongmin Zhang, Salvatore Filippone, Juan Yang, Pierre Sinaÿ, André Rassat, Ruth Edge, Suppiah Navaratnam, David J. McGarvey, Edward J. Land, Michael Brettreich, Andreas Hirsch, René V. Bensasson. Chemical Physics 2006, 325, 397-403.

 -      “Alkylalanes and methyl furanosides: regioselective O-debenzylation or acetal cleavage”. Cai Jia, Yongmin Zhang, Li-He Zhang, Pierre Sinaÿ, Matthieu Sollogoub. Carbohydr. Res. 2006, 341, 2135-2144.

 -    “Chemical constituents of Gentiana macrophylla Pall. from Shaanxi”. Qianliang Chen, Wenji Sun, Guangzhong Tu, Zhangyan Shi, Yongmin Zhang. Natural Product Communications  2006, 1, 527-530.