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  • 姓  名:毛旭明
  • 职称职务:教授,博士生导师
  • 联系电话:0571-88208569
  • 电子邮箱:xmmao@zju.edu.cn
  • 办公地址:浙江大学紫金港校区生命科学学院340室
个人简介

一、学习工作经历

1、学历背景:

1997.9-2001.7,复旦大学,生命科学学院,本科

2001.9-2006.8,中国科学院,上海生命科学研究院,生物化学与细胞生物学研究所,博士

2、国外学习研究经历:

2013.5-2015.5,美国加州大学洛杉矶分校(University of California, Los Angeles. UCLA),访问学者

3、工作经历:

2006.9-2007.4,       浙江大学,生命科学学院,智力引进教师

2007.5-2009.5,       浙江大学,生命科学学院,师资博士后

2009.5-2010.12,      浙江大学,生命科学学院,助理研究员

2011.1-2015.12,      浙江大学,生命科学学院,副教授

2016.1-至今,         浙江大学,药学院,教授

二、研究方向

1、基于合成生物学、现代分子生物学的生物制药工程;

2、微生物药物的挖掘,生物合成机制及结构活性改造;

3、微生物次级代谢调控机制。

三、主要研究成果

(一)论文

21. Mao XM#,Zhan ZJ#, Grayson MN, Tang MC, Xu W, Li YQ, Yin WB, Lin HC, Chooi YH, Houk KN, Tang Y*. Efficient Biosynthesis of Fungal Polyketide Containing the Dioxabicyclo-octane Ring System. J Am Chem Soc. 2015. 137(34): 11904-11907.

20. Mao XM#,Xu W,Li D,Yin WB,Chooi YH,Li YQ,Tang Y*,Hu Y*#. EpigeneticGenomeMiningof anEndophyticFungusLeadsto the Pleiotropic Biosynthesis of Natural Products. Angew Chem Int Ed Engl.2015. 54(26): 7592-6.

19. Mao XM*,Luo S,Zhou RC,Wang F,Yu P,Sun N,Chen XX,Tang Y,Li YQ*. Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporusby an autoregulator, AtrA. J Biol Chem.2015. 290(12): 7992-8001.

18. Liu SP, Yu P, Yuan PH, Zhou ZX, Bu QT, Mao XM, Li YQ*. Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensisL10. ApplMicrobiolBiotechnol. 2015. 99(6): 2715-26.

17. Wang F, Ren NN, Luo S, Chen XX, Mao XM*, Li YQ*. DptR2, a DeoR-type auto-regulator, is required for daptomycin production in Streptomyces roseosporus.Gene. 2014. 544(2): 208-215.

16. Mao XM, Ren NN, Sun N, Wang F, Zhou RC, Tang Y, Li YQ*. Proteasome involvement in a complex cascade mediating SigT degradation during differentiation of Streptomycescoelicolor.FEBS Lett. 2014. 588(4): 608-13.

15. Chen Z, Li J, Wang W, Guo X, Li Y, Mao X, Chen X, Guan W*. Mutations adjacent to the end of transmembrane helices 6 and 7 independently affect drug efflux capacity of yeast ABC transporter Pdr5p.BiochimBiophysActa. 2014. 1838(3): 932-9.

14. Mao XM, Sun N, Wang F, Luo S, Zhou Z, Feng WH, Huang FL, Li YQ*. Dual positive feedback regulation of protein degradation of an extra-cytoplasmic function σ factor for cell differentiation in Streptomyces coelicolor.J Biol Chem. 2013. 288(43): 31217-28.

13. Mao XM, Sun ZH, Liang BR, Wang ZB, Feng WH, Huang FL, Li YQ*. Positive feedback regulation of stgR expression for secondary metabolism in Streptomyces coelicolor.J Bacteriol. 2013. 195(9):2072-8.

12. Sun N, Wang ZB, WuHP, MaoXM*, Li YQ. Construction of over-expression shuttle vectors in Streptomyces.Ann Microbiol. 2012. 62(4): 1541-1546.

11. Guo X, Li J, Wang T, Liu Z, Chen X, Li Y, Gu Z, Mao X, Guan W*, Li Y*. A mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5p.PLoS One. 2012. 7(1): e29520.

10. Shen X, Li S, Du Y, Mao X, Li Y*. The N-terminal hydrophobic segment of Streptomycescoelicolor FtsY forms a transmembrane structure to stabilize its membrane localization.FEMS Microbiol Lett. 2012. 327(2): 164-71.

9. Feng WH, Mao XM, Liu ZH, Li YQ*. The ECF sigma factor SigT regulates actinorhodin production in response to nitrogen stress in Streptomyces coelicolor.ApplMicrobiolBiotechnol. 2011. 92(5): 1009-21.

8. Wang C, Long X, Mao X, Dong H, Xu L, Li Y*. SigN is responsible for differentiation and stress responses based on comparative proteomic analyses of Streptomyces coelicolor wild-type and sigN deletion strains.Microbiol Res. 2010. 165(3): 221-31.

7. Mao XM, Zhou Z, Cheng LY, Hou XP, Guan WJ, Li YQ*. Involvement of SigT and RstA in the differentiation of Streptomyces coelicolor.FEBS Lett. 2009. 583(19): 3145-50.

6. Mao XM, Zhou Z, Hou XP, Guan WJ, Li YQ*.Reciprocal regulation between SigK and differentiation programs in Streptomyces coelicolor.J Bacteriol. 2009. 191(21): 6473-81.

5. Li YD, Xie ZY, Du YL, Zhou Z, Mao XM, Lv LX, Li YQ*. The rapid evolution of signal peptides is mainly caused by relaxed selection on non-synonymous and synonymous sites.Gene. 2009. 436(1-2): 8-11.

4. Mao X, Nie X, Cao F, Chen J*. Functional analysis of ScSwi1 and CaSwi1 in invasive and pseudohyphal growth of Saccharomyces cerevisiae.ActaBiochimBiophys Sin (Shanghai). 2009. 41(7): 594-602.

3. Mao X, Li Y, Wang H, Cao F, Chen J*. Antagonistic interplay of Swi1 and Tup1 on filamentous growth of Candida albicans.FEMS Microbiol Lett. 2008. 285(2): 233-41.

2. Li Y, Su C, Mao X, Cao F, Chen J*. Roles of Candida albicans Sfl1 in hyphal development.Eukaryot Cell. 2007. 6(11): 2112-21.

1. Mao X, Cao F, Nie X, Liu H, Chen J*. The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans.FEBS Lett. 2006. 580(11): 2615-22.

(二)课题

7、国家自然科学基金面上项目,31571284,2016-2019;

6、国家自然科学基金面上项目,31370103,2014-2017;

5、“863”计划子课题,2012AA02A706,2012-2015;

4、浙江省自然科学基金面上项目,Y2100570,2010-2012;

3、浙江大学优秀青年教师资助计划(紫金计划),2008-2010;

2、国家自然科学基金青年基金,30700006,2008-2010;

1、中国博士后科学基金,2007-2009。

(三)专利

1.陈江野,毛旭明。中国发明专利,白色念珠菌转录激活因子基因及其用途。专利号:ZL03150427.2。2007.

2. 陈江野、毛旭明。中国发明专利,白念珠菌菌丝调控因子基因及其用途。专利号:ZL200510030527.X。2010.

四、主要荣誉

2013年获“青年岗位能手”称号。

五、社会兼职

浙江省微生物学会青年理事。