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  • 姓  名:孙莲莉
  • 职称职务:副教授、硕士生导师
  • 联系电话:0571-88208407
  • 电子邮箱:sunlianli@zju.edu.cn
  • 办公地址:
个人简介

一、工作经历:

2014.06-至今     浙江大学药学院         副教授

2012.06-2014.5    浙江大学生仪学院        讲师

2009.05-2012.05   浙江大学药学院          博士后

2008.07-2009.04   德国美因茨大学药学院    博士后

二、教育经历:

2005.09-2008.06   德国美因茨大学药学院  生物制药专业(联合培养)

2003.09-2008.06   浙江大学药学院        药物分析专业   理学博士

1999.09-2003.06   浙江大学药学院        药学专业       理学学士

三、研究方向:

运用结构生物学和分子生物学的方法对天然活性代谢酶进行系统研究,包括酶克隆、表达、纯化、结晶及三维结构解析。

四、科研成果:

1. L Sun, M Luan, W Zhu, S Gao, Q Zhang, C Xu, X Lu, X Xu, J Tian, L Zhang. Study on antitubercular constituents from the seeds of Nigella glandulifera, Chem.  Pharm. Bull., 2013, 61, 873-876.

2. L Sun, Y Chen, C Rajendran, U Mueller, S Panjikar, M Wang, R Mindnich, C Rosenthal, TM Penning, J Stöckigt. Crystal structure of perakine reductase, a founding member of a novel aldo-keto reductase (AKR) subfamily which undergoes unique conformational changes during NADPH binding,J. Biol. Chem. 2012, 287, 11213-11221.

3. F Wu, H Zhu, L Sun, C Rajendran, M Wang, X Ren, S Panjikar, A Cherkasov, H Zou, J Stöckigt. Scaffold tailoring by a newly detected Pictet−Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework. J. Am. Chem. Soc. 2012, 134, 1498-1500.(‡ Co-first)

4. L Zhang, X Li, W Zheng, Z Fu, W Li, L Ma, K Li, L Sun, J Tian. Proteomics analysis of UV-irradiated Lonicera japonica Thunb. with bioactive metabolites enhancement. Proteomics, 2013, 13, 3508-3522.

5. Z Fu, L Zhang, X Liu, Y Zhang, Q Zhang, X Li, W Zheng,L Sun, J Tian. Comparative proteomic analysis of the sun- and freeze-dried earthworm Eisenia fetida with differentially thrombolytic activities.J. Proteomics, 2013, 83, 1-14.

6. X Wang, L Sun, K Huang, S Shi, L Zhang, J Xu, H Peng, X Sun, L Wang, X Wu, Y Zhao, X Li, J Stöckigt, J Qu. Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolace. Chemistry & Biodiversity, 2009, 6, 1053-1065.

7. L Sun, M Ruppert, Y Sheludko, H Warzecha, Y Zhao, J Stöckigt. Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia,Plant Mol. Biol. 2008, 67, 455-467

五、科研项目:

1. 国家自然科学基金 (负责)新型生物催化剂Perakine还原酶复合物结构解析及其在抗肿瘤吲哚生物碱构建的应用,2014-2016

2. 教育部博士点专项基金新教师类(负责)基于三维结构的Perakine还原酶合理酶设计及其在抗肿瘤活性化合物构建的应用,2014-2016

3. 浙江省教育厅科研项目(负责)新型植物AKR,Perakine还原酶复合物结构生物学研究及其应用,2013-2015