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  • 姓  名:蔡圣
  • 职称职务:讲师
  • 联系电话:0571-88208407
  • 电子邮箱:caisheng@zju.edu.cn
  • 办公地址:药学院205室
个人简介

一、教育经历:

2008 - 2013  复旦大学药学院,药物分析,博士研究生

2003 - 2007  浙江大学药学院,药学专业,本科 

 

二、工作经历:

2013 -至今 浙江大学药学院 讲师

2015 - 2016  美国德州大学奥斯汀分校,系统生物与合成生物,访问学者

 

三、研究方向:

1)药物分析新方法新技术研究:蛋白质、核酸等生物分子和药物的化学发光/荧光检测,纳米材料以及核酸适配体技术在药物分析中的应用。

2)蛋白多肽类药物的药物代谢动力学研究。 

1. 代表性论文:

1. Sheng Cai, Xueke Tian, Lianli Sun, Haihong Hu, Shirui Zheng, Huidi Jiang, Lushan Yu, and Su Zeng. Platinum(II)-Oligonucleotide Coordination Based Aptasensor for Simple and Selective Detection of Platinum Compounds. Analytical Chemistry, 2015, 87, 10542-10546.

2. Sheng Cai, Choiwan Lau and Jianzhong Lu, “Turn-On” Chemiluminescence Sensor for the Highly Selective and Ultrasensitive Detection of Hg2+ Ions Based on Interstrand Cooperative Coordination and Catalytic Formation of Gold Nanoparticles. Analytical Chemistry, 2011, 83, 9702-9708. 

3. Sheng Cai, Choiwan Lau and Jianzhong Lu, Turn-on Aptameric System for Simple and Selective Detection of Protein via Base Stacking-dependent DNA Hybridization Event. Analytical Chemistry, 2011, 83, 5844-5850. 

4. Sheng Cai, Choiwan Lau and Jianzhong Lu, Sequence-Specific Detection of Short-Length DNA via Template-Dependent Surface-Hybridization Events. Analytical Chemistry, 2010, 82, 7178-7184. 

5. Sheng Cai, Liang Xin, Choiwan Lau, Jianzhong Lu and Xueji Zhang, Ultrasensitive and selective DNA detection by hydroxylamine assisted gold nanoparticle amplification. Chemical Communications, 2011, 47, 6120-6122. 

6. Sheng Cai, Zhijuan Cao, Choiwan Lau and Jianzhong Lu, Label-free technology for the amplified detection of microRNA based on the allosteric hairpin DNA switch and hybridization chain reaction† Analyst, 2014, 139, 6022–6027 

7. Sheng Cai, Liang Xin, Choiwan Lau and Jianzhong Lu, Highly sensitive non-stripping gold nanoparticles-based chemiluminescent detection of DNA hybridization coupled to magnetic beads. Analyst, 2010, 135, 615-620. 

8. Sheng Cai, Yanhua Sun, Choiwan Lau, Jianzhong Lu, Sensitive chemiluminescence aptasensor based on exonuclease-assisted recycling amplification. Analytica Chimica Acta, 2013, 761, 137-142. 

9. Aiping Fan, Sheng Cai, Zhijuan Cao, Choiwan Lau and Jianzhong Lu, Hydroxylamine- amplified gold nanoparticles for the homogeneous detection of sequence-specific DNA. Analyst, 2010, 135, 1400-1405. 

10. Yanhua Sun, Sheng Cai, Zhijuan Cao, Choiwan Lau and Jianzhong Lu, Aptameric system for the highly selective and ultrasensitive detection of protein in human serum based on non stripping gold nanoparticles. Analyst, 2011, 136, 4144-4151.

 2. 主持基金项目:

1. 国家自然科学青年基金:基于配位结合的铂离子化学发光适配体检测新技术,2015-2017年,负责人

2. 浙江省自然科学青年基金:基于适配体构象转化和信号放大的MicroRNA化学发光检测新技术,2014-2016,负责人

3. 浙江省科技厅 小分子药物研发关键技术科技创新团队 自主项目:基于构象转化的miRNA化学发光适配体检测新技术研究 2013-2015,负责人

 

四、主要荣誉:

2011 教育部博士研究生学术新人奖