教职员工

快速导航

当前位置:首页 >> 教职员工 >> 教工信息
  • 姓  名:周慧
  • 职称职务:副教授、硕士生导师
  • 联系电话:0571-88208408
  • 电子邮箱:zhouhui@zju.edu.cn
  • 办公地址:浙江大学药学院药物所207室
个人简介

个人简介

一、学习工作经历

教育背景:

   1992-1996 四川联合大学化学系,理学学士

   1999-2005 浙江大学化学系,理学博士

研究工作经历:

    1996-1999 江西中医学院药学系,助教

    2005-2007 浙江大学药学院,博士后

    2007-2011 浙江农林大学林业与生物技术学院,副研究员

    2011-2013 浙江大学药学院,副研究员

    2013-至今 浙江大学药学院,副教授

二、研究方向
    质谱分析、药物分析

    临床前药代动力学研究

     药物代谢与药物转运

三、主要研究成果
1、论文

[1] Siyuan Sun, Kai Wang, Hongmei Lei, Liping Li, Meijuan Tu, Su Zeng,Hui Zhou*, Huidi Jiang*. Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Prog Neuropsychopharmacol Biol Psychiatry, 2014; 49:1–6.

[2] Lushan Yu, Qi Shen, Quan Zhou, Huidi Jiang, Huichang Bi, Min Huang, Hui Zhou*, Su Zeng. In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs. J Ethnopharmacol, 2013; 150: 485-491.

[3] Ye Tian, Sainan Qian, Yan Jiang, Qi Shen, Jiang Zheng, Hui Zhou*, Su Zeng*. The interaction between human breast cancer resistance protein(BCRP) and five bisbenzylisoquinoline alkaloids. Int J Pharmaceut, 2013; 311: 225-230.

[4] Meijuan TuSiyuan SunKai WangXueying PengRuihan WangLiping LiSu ZengHui Zhou*, Huidi Jiang*. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology, 2013; 311:225-230.

[5] Meng Chen, Yan Lou, Yaodong Wu, Zhaoke Meng, Liping Li, Lushan Yu, Su Zeng , Hui Zhou*, Huidi Jiang*. Characterization of in vivo and in vitro metabolites of furanodiene in rats by high performance liquid chromatography – electrospray ionization mass spectrometry and nuclear magnetic resonance spectra. J Pharm Biomed Anal, 2013; 86:161-168.

[6] Zhong-Jian Chen, Yan-Qing Dai, Si-Si Kong, Fei-Feng Song, Li-Ping Li, Jian-Feng Ye, Ru-Wei Wang, Su Zeng, Hui Zhou* and Hui-Di Jiang*. Luteolin is a rare substrate of human catechol-O-methyltransferase favoring a para-methylation. Mol Nutr Food Res, 2013; 57(5):877-885.

[7] Si-Yuan Sun, Yu-Qing Wang, Liping Li, Lu Wang, Su Zeng, Hui Zhou*, Hui-Di Jiang*. Stereoselective interaction between tetrahydropalmatine enantiomers and CYP enzymes in human liver microsomes. Chirality, 2013; 25:43-47.

[8] Hui Zhou, Junling Liang, Da Lv, Yinfei Hu, Yan Zhu, Jinping Si*, Shihua Wu*. Characterization of phenolics of Sarcandra glabra by non-targeted high-performance liquid chromatography fingerprinting and following targeted electrospray ionisation tandem mass spectrometry /time-of-flight mass spectrometry analyses. Food Chem,2013,138(4):2390-2398.

[9] Hui Zhou, Liping Li, Huidi Jiang, Su Zeng*. Identification of three new N-demethylated and o-demethyled bisbenzylisoquinoline alkaloid metabolites of isoliensinine from dog hepatic microsomes. Molecules, 2012;17(10):11712-11720.

[10] Hui Zhou, Huidi Jiang, Tongwei Yao, Su Zeng*. Fragmentation study on phenolic alkaloids neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine. Rapid Commun Mass Spectrom. 2007; 21(13): 2120-8.

2、课题
     [1] 浙江省自然科学基金,基于肾脏转运体的顺铂减毒作用研 究,2014.01-2016.12.

[2] 国家自然科学基金,甲基莲心碱及其代谢物莲心碱和异莲心碱的吸收代谢机理研究,2012.01-2014.12.

[3] 高等学校博士学科点专项科研基金,应用人源化转基因细胞体系研究调控Nef代谢的分子机制,2012.01-2014.12.